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Noninvasive Fetal RHD Genotyping Using Cell-Free Fetal DNA (2.04.108)

Blue Shield of California·CA · OB-GYN, Genetics·Medical Policy
Effective date
Apr 1, 2026
We identified it
Apr 1, 2026
Days to comply

Summary

Blue Shield of California updated their policy for noninvasive fetal RHD genotyping using cell-free DNA, clarifying coverage criteria and removing the discontinued SensiGene test from consideration. The policy covers testing when pregnancy is at risk for alloimmunization, paternal typing is unavailable/heterozygous, and amniocentesis is declined/contraindicated.

Action Required

Action needed
Before April 1, 2026: Review current billing practices for noninvasive fetal RHD genotyping to ensure claims meet the three required criteria (maternal RhD negative status or antibodies present, paternal antigen typing unavailable/heterozygous, amniocentesis declined/contraindicated). Update prior authorization workflows to verify these criteria are documented. Stop referencing SensiGene test as it's no longer available.