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Multimarker Serum Testing Related to Ovarian Cancer

Blue Cross & Blue Shield of Mississippi·MS · OB-GYN, Oncology·Medical Policy
Effective date
Not stated
We identified it
Jun 20, 2026
Days to comply
—

Summary

BCBS Mississippi has classified all uses of multimarker serum tests for ovarian cancer (OVA1, Overa, and ROMA tests) as investigational and not covered. These tests are commonly used to assess adnexal masses and triage patients for potential malignancy referrals to gynecologic oncologists.

Action Required

Action needed
Immediately: Billing team must stop submitting claims for OVA1, Overa, and ROMA multimarker serum tests to BCBS Mississippi as they are now classified as investigational. Update billing system to flag these tests as non-covered. Inform providers that these tests will not be reimbursed and patients should be notified of potential out-of-pocket costs if ordered.

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