CommercialCoverageMedium impact
First-Trimester Detection of Down Syndrome Using Fetal Ultrasound Markers Combined with Maternal Serum Assessment
Blue Cross & Blue Shield of Mississippi·MS · OB-GYN, Family Medicine·Medical Policy
We identified it
Jun 20, 2026
Summary
BCBS Mississippi updated their policy for first-trimester Down syndrome screening. Combined nuchal translucency with maternal serum markers remains covered as medically necessary, but nuchal translucency alone and fetal nasal bone assessment remain investigational (non-covered).
Action Required
Billing team must verify that first-trimester Down syndrome screening claims include both nuchal translucency AND maternal serum markers (CPT 84163, 84702) to ensure coverage. Claims for nuchal translucency alone (CPT 76813, 76814) or fetal nasal bone assessment will be denied as investigational. Update billing edits to flag standalone nuchal translucency claims.