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Opioid Antagonists under Heavy Sedation or General Anesthesia as a Technique of Opioid Detoxification
Blue Cross & Blue Shield of Mississippi·Anesthesiology, Pain Management, Psychiatry·Medical Policy
Effective date
Aug 1, 2025
We identified it
Jun 20, 2026
Summary
This policy confirms that ultra-rapid opioid detoxification using opioid antagonists under heavy sedation or general anesthesia remains classified as investigational and is not covered. The policy was recently reviewed on 08/01/2025 with no changes to the coverage determination.
Action Required
No immediate action required. Continue to deny claims for ultra-rapid opioid detoxification procedures using CPT code 01999 when used for this investigational technique. Inform providers that this procedure remains non-covered as investigational.