CommercialCoverageMedium impact
Plasma Exchange
Blue Cross & Blue Shield of Mississippi·MS · Nephrology, Hematology, Neurology +3 more·Medical Policy
We identified it
Jun 20, 2026
Summary
BCBS Mississippi updated their plasma exchange (plasmapheresis) medical policy defining covered versus investigational applications. The policy specifies medical necessity criteria for various autoimmune, hematologic, neurologic, renal diseases and transplantation scenarios, while listing many conditions as investigational (non-covered).
Action Required
Immediately: Review all pending and future plasma exchange prior authorization requests against the new medical necessity criteria. Ensure documentation supports covered conditions (severe mixed cryoglobulinemia, TTP, Guillain-Barré syndrome, etc.) versus investigational uses (chronic fatigue, asthma, psoriasis, etc.). Update prior auth templates to reference specific policy requirements for each covered condition.