All PlansBilling CodesMedium impact
Allergy Immunotherapy
Blue Cross & Blue Shield of Mississippi·MS · Allergy & Immunology, Family Medicine, Internal Medicine +1 more·Medical Policy
Effective date
Oct 1, 2025
We identified it
Jun 20, 2026
Summary
New ICD-10 diagnosis codes Z91.0110, Z91.0111, Z91.0112, Z91.0120, Z91.0121, and Z91.0122 have been added for allergy immunotherapy billing effective October 1, 2025. The policy confirms that immunotherapy injections should be billed by injection (not by dose) and antigen provision should be billed by dose or vial based on CPT descriptors.
Action Required
By October 1, 2025: Billing team must update coding systems to include new ICD-10 diagnosis codes Z91.0110, Z91.0111, Z91.0112, Z91.0120, Z91.0121, and Z91.0122 for allergy immunotherapy claims. Verify billing software is configured to bill immunotherapy by injection (not by dose) and antigen provision by dose or vial according to CPT descriptors.