CommercialCoverageMedium impact
State and School Employees' Health Insurance Plan - Ryoncil (remestemcel-L-rknd)
Blue Cross & Blue Shield of Mississippi·MS · Oncology, Hematology, Pediatrics·Medical Policy
Effective date
Oct 15, 2025
We identified it
Jun 20, 2026
Summary
Mississippi State and School Employees' Health Insurance Plan has designated Ryoncil (remestemcel-L-rknd) as not medically necessary for treating steroid-refractory acute graft versus host disease in pediatric patients. All services related to delivery and administration of this medication will also be denied as not medically necessary.
Action Required
Immediately: Update billing system to flag HCPCS code J3402 (remestemcel-l-rknd injection) as non-covered for Mississippi State and School Employees' Health Insurance Plan members. Billing team must deny or reject claims for this code and related administration services. Notify providers that alternative covered treatments must be used for steroid-refractory acute graft versus host disease in pediatric patients.