CommercialCoverageMedium impact
Ryoncil (remestemcel-L-rknd)
Blue Cross & Blue Shield of Mississippi·MS · Oncology, Hematology, Pediatrics·Medical Policy
Effective date
Oct 15, 2025
We identified it
Jun 20, 2026
Summary
BCBS Mississippi has added a new policy classifying Ryoncil (remestemcel-L-rknd) injections as not medically necessary for treating steroid-refractory acute graft versus host disease in pediatric patients. The policy specifically denies coverage for HCPCS code J3402 and requires prior authorization for any administration services.
Action Required
Immediately: Billing team must update system to flag HCPCS code J3402 (Ryoncil injections) as non-covered for BCBS Mississippi plans. Add alert in billing software that prior authorization is required for any administration services related to this medication. Claims for J3402 will be denied as not medically necessary unless alternative covered treatments are exhausted and documented.