CommercialBilling CodesMedium impact
Tumor-Informed Circulating Tumor DNA Testing for Cancer Management
Blue Cross & Blue Shield of Mississippi·MS · Oncology, Hematology·Medical Policy
Effective date
Apr 1, 2025
We identified it
Jun 20, 2026
Summary
BCBS Mississippi updated their policy on circulating tumor DNA (ctDNA) testing for cancer management, adding new CPT code 0539U effective April 1, 2025. All tumor-informed ctDNA testing including Signatera remains investigational and non-covered for all indications.
Action Required
By April 1, 2025: Billing team must update system to include new CPT code 0539U for solid tumor ctDNA testing in the investigational/non-covered category. Ensure all ctDNA testing codes (0340U, 0530U, 0539U, 81479) are flagged as investigational to prevent automatic billing. Claims for these services will likely be denied without prior authorization or may not be covered at all.