CommercialCoverageMedium impact
Zurzuvae (zuranolone)
Blue Cross & Blue Shield of Mississippi·MS · OB-GYN, Psychiatry, Family Medicine +1 more·Medical Policy
We identified it
Jun 20, 2026
Summary
Zurzuvae (zuranolone) for postpartum depression is considered not medically necessary by BCBS Mississippi, as other covered alternatives exist for treating postpartum depression. State Health Plan employees may have coverage through their pharmacy benefit manager with prior authorization.
Action Required
Immediately: Before prescribing Zurzuvae for postpartum depression, providers must perform formulary drug search on patient's member ID to verify coverage. For State Health Plan patients, check https://www.dfa.ms.gov/cvs-caremark and submit prior authorization requests to the pharmacy benefit manager. Billing team should expect denials for Zurzuvae unless patient has State Health Plan coverage with approved prior authorization.