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Blue Cross & Blue Shield of MississippiCommercial · Billing Codes · Medical Policy · OphthalmologyMedium impact

Endothelial Keratoplasty

Effective date
Not stated in the notice
Identified
Jun 20, 2026

Summary

Blue Cross Blue Shield Association policy 9.03.22, now listed as BCBSMS policy L.9.03.412, states that endothelial keratoplasty (Descemet stripping endothelial keratoplasty, Descemet stripping automated endothelial keratoplasty, Descemet membrane endothelial keratoplasty, or Descemet membrane automated endothelial keratoplasty) may be considered medically necessary for endothelial dysfunction, including ruptures in Descemet membrane, endothelial dystrophy, aphakic and pseudophakic bullous keratopathy, iridocorneal endothelial syndrome, corneal edema attributed to endothelial failure, and failure or rejection of a previous corneal transplant. Femtosecond laser-assisted endothelial keratoplasty and femtosecond and excimer laser-assisted endothelial keratoplasty are considered investigational, and endothelial keratoplasty is considered investigational when endothelial dysfunction is not the primary cause of decreased corneal clarity. The most recent policy update, dated 03/11/2026, removed ICD-9 diagnosis codes from the policy.

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What to do

Action · 7 steps
01Billing team: Before billing endothelial keratoplasty, confirm the documentation shows endothelial dysfunction for one of the listed indications: ruptures in Descemet membrane, endothelial dystrophy, aphakic and pseudophakic bullous keratopathy, iridocorneal endothelial syndrome, corneal edema attributed to endothelial failure, or failure or rejection of a previous corneal transplant.
02Document that endothelial dysfunction is the primary cause of decreased corneal clarity, because the policy considers endothelial keratoplasty investigational when it is not.
03Femtosecond laser-assisted endothelial keratoplasty and femtosecond and excimer laser-assisted endothelial keratoplasty are considered investigational, and investigational services are not considered medically necessary under the policy definitions.
04Endothelial keratoplasty should not be used in place of penetrating keratoplasty for conditions with concurrent endothelial disease and anterior corneal disease, such as concurrent anterior corneal dystrophies, anterior corneal scars from trauma or prior infection, and ectasia after previous laser vision correction surgery.
05Clinical input has suggested that anterior corneal disease should not be an exclusion in some cases, particularly if endothelial disease is the primary cause of the decrease in vision.
06BCBSMS makes no payment for services, treatments, procedures, equipment, drugs, devices, items or supplies which are not documented to be Medically Necessary.
07The coverage guidelines should not be used in lieu of the member's specific benefit plan language, and Federal Employee Program may dictate that FDA-approved devices are assessed only on medical necessity.

Codes mentioned

6575665757H21.261H21.262H21.263H21.269H18.231H18.232H18.233H18.239H18.10H18.13H18.331H18.332H18.333H18.339H18.511H18.512H18.513H18.519T85.318AT85.328AT85.398AT85.318DT85.318ST85.328DT85.328ST85.398DT85.398ST86.8401T86.8402T86.8403T86.8409T86.8411T86.8412T86.8413T86.8419

Original notice

Endothelial Keratoplasty
bcbsms.com · Always check the source before changing claims.
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