Who is affected by this change?

This affects Blue Cross & Blue Shield of Mississippi Neurology providers on All Plans plans.

When does this change take effect?

This change is effective Jan 1, 2025.

Which billing codes are affected?

The following codes are affected: 83884, 84999.

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All PlansBilling CodesMedium impact

Serum Biomarker Tests for Multiple Sclerosis

Blue Cross & Blue Shield of Mississippi·Neurology·Medical Policy

Effective date

Jan 1, 2025

We identified it

Jun 20, 2026

Days to comply

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Summary

New CPT codes 0547U, 83884, and 0623U have been added to the investigational codes list for serum biomarker tests for multiple sclerosis. All serum biomarker tests for MS remain non-covered and considered investigational.

Action Required

Action needed

By January 1, 2025: Billing team must update system to flag CPT codes 0547U, 83884, and 0623U (effective April 1, 2025 and April 1, 2026 respectively) as investigational/non-covered for multiple sclerosis serum biomarker testing. Update denial reason codes to indicate these tests are considered investigational. Claims for these codes will be denied.

Affected Billing Codes

83884

84999

Related policy hubs

Blue Cross & Blue Shield of Mississippi policies Neurology Code 83884 Code 84999