All PlansCoverageMedium impact
Sphenopalatine Ganglion Block for Headache
Blue Cross & Blue Shield of Mississippi·MS · Neurology, Pain Management, Anesthesiology +1 more·Medical Policy
We identified it
Jun 20, 2026
Summary
Sphenopalatine ganglion blocks for all headache conditions (including migraines, cluster headaches, and post-dural puncture headaches) are now considered investigational and not covered. This affects CPT code 64400 which was recently added to the policy in 2022.
Action Required
Immediately: Billing team must flag CPT code 64400 (sphenopalatine ganglion blocks) as investigational/non-covered in billing system. Stop submitting claims for SPG blocks for headache treatment to avoid denials. Notify providers that these procedures are not covered for any headache indication.