MedicaidAdministrativeMedium impact
20-002 Be Aware of Opioid Potentiator Medications
Health Net·CA · Family Medicine, Internal Medicine, Pain Management +1 more·Pharmacy
We identified it
Jun 20, 2026
Summary
Health Net and CalViva Health issued guidance for Medi-Cal providers in Fresno, Kings and Madera counties about opioid potentiator medications that enhance opioid effects and increase risks of respiratory depression, coma and death. This is educational guidance to help providers assess drug interactions when prescribing opioids with other medications like benzodiazepines, antihistamines, muscle relaxants, and certain antibiotics.
Action Required
Immediately: Providers should review the opioid potentiator medication list and consider drug interactions when prescribing opioids with benzodiazepines, antihistamines, antipsychotics, muscle relaxants, gabapentinoids, certain antibiotics, antifungals, HIV drugs, or stimulants. Clinical staff should incorporate this guidance into prescription review workflows to assess risks and benefits of opioid combinations for patient safety.