MedicaidAdministrativeMedium impact
25-1199m Opioid Interactions: Potentiator Drugs That Increase the Risk of Overdose
Health Net·CA · Family Medicine, Internal Medicine, General Practice +3 more·Provider News
Effective date
Nov 21, 2025
We identified it
Jun 20, 2026
Summary
HealthNet California has issued new guidance on opioid drug interactions, specifically identifying potentiator drugs that increase overdose risk when combined with opioids. This clinical advisory applies to various provider types in Medi-Cal counties and includes a downloadable educational flyer.
Action Required
Immediately: Clinical staff should download and review the opioid drug interactions flyer from HealthNet's provider library. Providers prescribing opioids must be aware of potentiator drugs that increase overdose risk. Update clinical protocols to screen for these drug interactions during prescribing decisions.