MedicaidCoverageMedium impact
High Risk Therapies Clinical Edit
Missouri Medicaid (MO HealthNet)·MO · Family Medicine, Internal Medicine, Pain Management +2 more·Provider Notice
Effective date
Apr 15, 2021
We identified it
Jun 20, 2026
Summary
MO HealthNet implemented a new clinical edit requiring naloxone (opioid reversal agent) to be present when patients are prescribed both opioids and benzodiazepines concurrently. This high-risk therapy combination edit includes detailed naloxone dispensing protocols and patient education requirements for Missouri providers.
Action Required
Missouri providers prescribing concurrent opioids and benzodiazepines must ensure patients have access to naloxone per MO HealthNet clinical criteria. Review the High Risk Therapies Clinical Edit document at the provided URL and implement naloxone co-prescribing protocols. Document naloxone availability in patient records when prescribing these high-risk medication combinations.