J7181 Insurance Policy Changes

Factor VIII Replacement Products (Hemophilia A) (Revised)

This is a revised Factor VIII replacement product prior authorization policy for Hemophilia A treatment, effective January 20, 2017, with most recent updates on December 17, 2025. The policy covers 18 Factor VIII products across two main indications: routine bleeding prophylaxis and on-demand bleeding control/perioperative management. All Factor VIII product requests now require prior authorization approval with specific clinical criteria documentation for Medicaid/Medicare Kentucky members.