High impact
Kymriah™ (tisagenlecleucel) (Revised)
Humana·Effective Aug 26, 2026
Humana Kentucky Medicaid has revised its Kymriah (tisagenlecleucel) prior authorization policy effective August 26, 2026. The policy maintains three distinct approval pathways for large B-cell lymphoma (DLBCL and follicular lymphoma) in adults ≥18 years, and B-cell precursor acute lymphoblastic leukemia (ALL) in patients up to 25 years. All approvals require prior authorization, are limited to one lifetime dose, and require lymphodepleting chemotherapy unless contraindicated. Key exclusions include prior gene therapy, prior anti-CD19/anti-CD3 therapies, active hepatitis B/C, HIV/AIDS, and (for lymphoma cases) prior allogeneic transplant or CNS lymphoma.