High impact
Policy Criteria Change
Arkansas Blue Cross Blue Shield·Effective Oct 28, 2026
Arkansas Blue Cross updated approval criteria for four biologic medications used to treat Crohn's disease and ulcerative colitis (Certolizumab pegol, Guselkumab, Mirikizumab-mrkz, and Infliximab/biosimilars). Key changes include standardized step-therapy requirements, mandatory documentation of conventional therapy trial or contraindication, and strict prohibitions on combination biologic therapy. The policy also adds new off-label coverage for immune-mediated toxicities associated with Infliximab. All changes are effective October 28, 2026.